The St. Louis Cardinals face an intriguing challenge on Saturday afternoon as Busch Stadium hosts a matinee contest between the Cardinals and the San Francisco Giants. The matchup is the second game of a weekend series between the National League powers. Jakob Junis is scheduled to start for San Francisco, with Dakota Hudson on the bump for St. Louis.

Caesars Sportsbook lists both sides at -110 (risk $110 to win $100) on the money line in the latest Cardinals vs. Giants odds. The over-under for total runs scored is nine, up a run from the opening line. Before making any Giants vs. Cardinals picks, you need to see the MLB predictions and betting advice from SportsLine's advanced computer simulation model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a sizzling start to the 2022 season. It's on a 31-19 roll on top-rated MLB money-line picks through five weeks, returning almost $800 for $100 players. Anyone following it has seen huge returns.

Now, the model has set its sights on Giants vs. Cardinals and just locked in its picks and MLB predictions. You can head to SportsLine now to see the picks. Now, here are several MLB betting lines and trends for Giants vs. Cardinals: 

  • Giants vs. Cardinals money line: Giants -110, Cardinals -110
  • Giants vs. Cardinals over-under: 9 runs 
  • Giants vs. Cardinals run line: Cardinals -1.5 (+180)
  • SF: The Giants are 8-5 on the road 
  • STL: The Cardinals are 8-7 at home
Featured Game| St. Louis Cardinals vs. San Francisco Giants

Why you should back the Giants

The Giants were elite in almost every category in 2021, and San Francisco projects well in run prevention in this matchup. They will send the 29-year-old right-hander Junis to the mound, and he has a 1.20 ERA in 15 innings this season. Junis has 15 strikeouts and only three walks, and he has enjoyed success against the Cardinals, posting a 3.05 career ERA. San Francisco's bullpen arrived in St. Louis with a top-two mark in the NL in wins above replacement and with stellar marks in ground ball rate (47.7 percent) and walk rate (less than three per nine innings). 

At present, the Cardinals rank below the National League average in home runs, hits, doubles, walks, on-base percentage and slugging percentage on offense, with the Giants boasting top-five marks in runs scored, home runs and on-base percentage in 2022.

Why you should back the Cardinals

St. Louis also has a very strong pitching projection. Hudson has a 3.56 ERA in six starts this season, and he boasts a stellar 3.18 ERA in his career since debuting in 2018. Hudson does his best work in keeping the ball out of the air, generating a 59.8 percent ground ball rate in 2022 and a 57.9 percent mark for his career. Right-handers struggle against Hudson to the tune of a .663 career OPS, and he has a 2.95 career ERA against the Giants. 

St. Louis also entered the weekend series with the National League's best bullpen ERA at 3.00, and Cardinals relievers have a walk rate of 2.85 per nine innings. The Giants entered the weekend dead-last in the NL in doubles and No. 12 in triples, with the Cardinals leading the National League in both stolen bases (27) and strikeout avoidance on offense.

How to make Giants vs. Cardinals picks

SportsLine's model is leaning over on the run total, and it says one side of the money line has all the value. You can only get the model's MLB picks at SportsLine.

So who wins Giants vs. Cardinals? And which side has all the value? Visit SportsLine now to see which side of Giants vs. Cardinals you need to jump on Saturday, all from the model that has crushed its MLB picks, and find out.